From the
http://www.cpsc.gov/about/cpsia/smbus/manufacturers.html#q1"I work part-time in my home making clothes and toys for kids. Am I affected by this law?
Yes, the law covers all manufacturers and importers -- large and small, domestic and foreign. All businesses, including handmade toy and apparel makers, crafters, those making charitable donations, and other small business must take appropriate steps to be sure that their products conform to all aspects of the law and safety standards, including the new lead content and phthalates limits (more on phthalates) and mandatory toy standards."
So the CPSIA does cover donations of goods, and all the exemptions & testing requirement are the same for someone donating something handmade or even gently used items.