I have 3 brands in my shop, and they really could be separated into 3 shops, but I like having an eclectic look. The way I tie it all together is by color and subject, which I'm not sure is the best way to go, but it works for now. I've read again and again that you should keep your best sellers on the front page and / or featured. But, I get a little tired of seeing the same best sellers there all the time (my best sellers haven't changed in years - they're TRULY best sellers), so I keep those somewhere on the front page and mix in seasonal items.